PDK2

pyruvate dehydrogenase kinase, isozyme 2

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

PDK2 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human PDK2 Protein (Recombinant GST) (Full Length) - LS-G29673

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.29 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PDK2 Protein (Recombinant GST, N-terminus) (aa187-276) - LS-G59554

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PDK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99807

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46 kDa

Price:

100 µg/$494

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Human PDK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68014

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46 kDa

Price:

20 µg/$1,107

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Human PDK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81240

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46 kDa

Price:

20 µg/$150

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Mouse PDK2 Protein (Recombinant His-T7) (aa155-379) - LS-G15320

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.0 kDa

Price:

10 µg/$280; 50 µg/$435; 100 µg/$695; 200 µg/$870; 1 mg/$1,972; 500 µg/$1,514; 5 mg/$3,039; 2 mg/$2,159

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