PDK1

pyruvate dehydrogenase kinase, isozyme 1

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

PDK1 (8)

Publications

No (8)

Tag

10His, N-terminus (1)

GST, N-terminus (1)

His (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (2)

Source

293T Cells (1)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human PDK1 Protein (Recombinant His) - LS-G3513

Source:

E. coli

Tag:

His

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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Human PDK1 Protein (Recombinant GST, N-terminus) (aa203-302) - LS-G59552

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse PDK1 Protein (Recombinant 10His, N-terminus) (aa27-434) - LS-G55978

Source:

Baculovirus

Tag:

10His, N-terminus

Price:

100 µg/$1,164; 20 µg/$475; 1 mg/$2,187

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PDK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99806

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.1 kDa

Price:

100 µg/$494

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Human PDK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68013

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.1 kDa

Price:

20 µg/$1,107

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Human PDK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81239

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.1 kDa

Price:

20 µg/$150

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Mouse PDK1 Protein (Recombinant His-T7) (aa172-399) - LS-G15031

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.7 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Human PDK1 Protein (Recombinant His-T7) (aa233-430) - LS-G15032

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.6 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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