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PDE4B

phosphodiesterase 4B, cAMP-specific

PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.

Gene Name: phosphodiesterase 4B, cAMP-specific
Family/Subfamily: Phosphodiesterase , PDE - cAMP-specific
Synonyms: PDE4B, Pde-ivb, PDE32, PDE4B5, PDEIVB, Phosphodiesterase 4b, DPDE4, PDE4B3
Target Sequences: NM_002600 NP_002591.2 Q07343

Publications (2)

1
Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus. Campbell SL, van Groen T, Kadish I, Smoot LHM, Bolger GB,. BMC neuroscience. 2017 18:77. (WB; Human) [Full Text Article] [PubMed:29197324] Related Antibodies: LS-C173292.
2
PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells. Amy M Chinn, Cristina Salmerón, Jihyung Lee, Krishna Sriram, Eyal Raz, Paul A Insel. Frontiers in pharmacology. 2022 April;13:833832. [Full Text Article] [PubMed:35387344] [PMC:PMC8977838] Related Antibodies: LS-B11018.

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Products
Proteins (11)
Over-Expression Lysate (6)
Recombinant (5)
PDE4B (11)
No (11)
GST, N-terminus (1)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (8)
Human (7)
Rat (1)
293T Cells (3)
Baculovirus (1)
E. coli (1)
HEK 293 Cells (5)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (1)
PDE4B Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PDE4B Protein - Purified recombinant protein PDE4B was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
83.2 kDa
20 µg/$1,107
PDE4B Protein - Purified recombinant protein PDE4B was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
83.2 kDa
20 µg/$1,107
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Baculovirus
His-GST
Less than 1.0 EU/µg protein (determined by LAL method).
92.2 kDa
50 µg/$721
PDE4B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
64.2 kDa
100 µg/$710
PDE4B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
83.2 kDa
100 µg/$710
PDE4B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
83.2 kDa
20 µg/$150
PDE4B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
83.2 kDa
20 µg/$215
PDE4B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
64.2 kDa
20 µg/$215
PDE4B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
83.2 kDa
100 µg/$494
PDE4B Protein - Recombinant  Phosphodiesterase 4B, cAMP Specific By SDS-PAGE
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E. coli
His-T7
31.1 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).