OAS2

2'-5'-oligoadenylate synthetase 2, 69/71kDa

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.

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Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

OAS2 (6)

Publications

No (6)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (4)

Species

Human (4)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human OAS2 Protein (Recombinant GST) (Full Length) - LS-G29563

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

105.2 kDa

Price:

2 µg/$439

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OAS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99788

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.6 kDa

Price:

100 µg/$494

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Human OAS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74234

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20 kDa

Price:

20 µg/$150

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Human OAS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74235

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.6 kDa

Price:

20 µg/$150

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OAS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120879

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20 kDa

Price:

100 µg/$494

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Human OAS2 Protein (Recombinant His) (aa11-346) - LS-G25639

Source:

E. coli

Tag:

His

Molecular Weight:

42.6 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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