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As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.
Gene Name: | nitrogen permease regulator-like 3 (S. cerevisiae) |
Synonyms: | NPRL3, -14 gene protein, CGTHBA, HS-40, MARE, RMD11, Protein CGTHBA, C16orf35 |
Target Sequences: | NP_853547.1 Q8VIJ8 |
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