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Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. ARC is phosphorylated by casein kinase II (CK2) and phosphorylation is necessary to prevent apoptosis.
Gene Name: | nucleolar protein 3 (apoptosis repressor with CARD domain) |
Family/Subfamily: | Apoptosis , not assigned-Apoptosis |
Synonyms: | NOL3, Apoptosis repressor with CARD, CARD2, FCM, NOP, Nucleolar protein 3, Nucleolar protein of 30 kDa, MYP, NOP30 |
Target Sequences: | NM_003946 NP_003937.1 O60936 |
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