NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

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Proteins (9)

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Over-Expression Lysate (4)

Recombinant (5)

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NFKB2 (9)

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His-T7 (3)

Myc-DDK (Flag) (6)

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Human NFKB2 Protein (Recombinant His-T7) (aa38-343) - LS-G14332

Source:

E. coli

Tag:

His-T7

Molecular Weight:

38.5 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human NFKB2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66450

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

96.5 kDa

Price:

20 µg/$1,107

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Human NFKB2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66451

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

96.5 kDa

Price:

20 µg/$1,107

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NFKB2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99779

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

96.5 kDa

Price:

100 µg/$710

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Human NFKB2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77742

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

96.5 kDa

Price:

20 µg/$150

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Human NFKB2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77743

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

96.5 kDa

Price:

20 µg/$215

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NFKB2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120016

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

96.5 kDa

Price:

100 µg/$494

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Chicken NFKB2 Protein (Recombinant His-T7) (aa37-342) - LS-G24517

Source:

E. coli

Tag:

His-T7

Molecular Weight:

38.5 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Mouse NFKB2 Protein (Recombinant His-T7) (aa25-224) - LS-G14331

Source:

E. coli

Tag:

His-T7

Molecular Weight:

24.8 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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