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Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
Gene Name: | nuclear receptor coactivator 5 |
Synonyms: | NCOA5, BA465L10.6, CIA, KIAA1637, Nuclear receptor coactivator 5, NCoA-5 |
Target Sequences: | Q9HCD5 Q9HCD5 |
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