MYOG / Myogenin

myogenin (myogenic factor 4)

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts.

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Proteins (6)

Type

Over-Expression Lysate (3)

Recombinant (3)

Target

MYOG / Myogenin (6)

Publications

No (6)

Tag

6His, N-terminus (2)

GST (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human MYOG / Myogenin Protein (Recombinant GST) (Full Length) - LS-G29429

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

50.38 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MYOG / Myogenin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77525

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.9 kDa

Price:

20 µg/$150

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MYOG / Myogenin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99765

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.9 kDa

Price:

100 µg/$494

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Human MYOG / Myogenin Protein (Over-Expression Lysate 6His, N-terminus) (Glu2-Asn224) - LS-G26675

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

27.3 kDa

Price:

100 µg/$298

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Human MYOG / Myogenin Protein (Recombinant 6His, N-terminus) (Glu2-Asn224) - LS-G26585

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

36 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Rat MYOG / Myogenin Protein (Recombinant His-T7) (aa4-219) - LS-G13369

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.0 kDa

Price:

50 µg/$492; 10 µg/$289; 200 µg/$982; 100 µg/$785; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309

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