MYD88

myeloid differentiation primary response 88

The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

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Products

Proteins (13)

Type

Over-Expression Lysate (6)

Recombinant (7)

Target

MYD88 (13)

Publications

No (13)

Tag

GST (1)

GST, N-terminus (1)

His (2)

His, N-Terminal (1)

His-GST (1)

Myc-DDK (Flag) (7)

Species

Human (8)

Mouse (1)

Rat (1)

Source

293T Cells (3)

E. coli (4)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human MYD88 Protein (Recombinant His, N-Terminal) (Ala2-Pro296) - LS-G96874

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

36 kDa

Price:

10 µg/$265; 100 µg/$365; 50 µg/$315

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Human MYD88 Protein (Recombinant His) - LS-G2111

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Mouse MYD88 Protein (Recombinant His) (aa32-265) - LS-G14202

Source:

E. coli

Tag:

His

Molecular Weight:

28.4 kDa

Price:

10 µg/$288; 50 µg/$482; 100 µg/$772; 200 µg/$965; 1 mg/$2,098; 500 µg/$1,627; 5 mg/$3,375; 2 mg/$2,288

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Human MYD88 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77491

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.1 kDa

Price:

20 µg/$150

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Human MYD88 Protein (Recombinant GST) (Full Length) - LS-G29413

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

58.3 kDa

Price:

2 µg/$439

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Human MYD88 Protein (Recombinant GST, N-terminus) (aa31-130) - LS-G59312

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MYD88 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77492

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$150

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Human MYD88 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77493

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

20 µg/$150

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Human MYD88 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66330

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.1 kDa

Price:

20 µg/$1,107

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MYD88 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129610

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

100 µg/$494

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MYD88 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128915

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

100 µg/$494

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MYD88 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99760

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.1 kDa

Price:

100 µg/$494

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Rat MYD88 Protein (Recombinant His-GST) (aa1-296) - LS-G24431

Source:

E. coli

Tag:

His-GST

Molecular Weight:

63.9 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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