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MYBL2, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
Synonyms: | MYBL2, B-MYB, Myb-like protein 2, Myb-related protein B, BMYB |
Target Sequences: | NM_002466 NP_002457.1 P10244 |
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