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MSX2 / MSH

msh homeobox 2

Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.

Gene Name: msh homeobox 2
Synonyms: MSX2, CRS2, HOX8, Homeobox protein Hox-8, Homeobox protein MSX-2, Msh homeo box 2, Parietal foramina 1, PFM1, MSH, Msh homeobox 2, Msh homeobox homolog 2, PFM, FPP
Target Sequences: NM_002449 NP_002440.2 P35548

Publications (1)

1
Msx1 and Msx2 gene expression is downregulated in the cadmium-induced omphalocele in the chick model. Doi T, Puri P, Bannigan J, Thompson J. Journal of pediatric surgery. 2010 45:1187-91. (IHC-P; Chicken) [PubMed:20620318] Related Antibodies: LS-C30675.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
MSX2 / MSH (5)
No (5)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
MSX2 / MSH Protein - 12.5% SDS-PAGE of human MSX2 stained with Coomassie Blue
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Wheat Germ Extract
GST
55 kDa
2 µg/$439
MSX2 / MSH Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MSX2 / MSH Protein - Purified recombinant protein MSX2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
28.7 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
28.7 kDa
20 µg/$150
MSX2 / MSH Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
28.7 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).