Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.
Gene Name: | membrane-spanning 4-domains, subfamily A, member 2 |
Synonyms: | MS4A2, ATOPY, FcERI, FCER1B, IGER, IgE Fc receptor subunit beta, IGHER, IGEL, APY, IgE responsiveness (atopic) |
Target Sequences: | NM_000139 NP_000130.1 Q01362 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.