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MPP4 / Discs Large Homolog 6 is a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Gene Name: | membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) |
Synonyms: | MPP4, ALS2CR5, DLG6, Discs large homolog 6, Discs, large homolog 6, MAGUK p55 subfamily member 4 |
Target Sequences: | NM_033066 NP_149055.1 Q96JB8 |
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