MCFD2

multiple coagulation factor deficiency 2

MCFD2 is a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LAMN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

MCFD2 (6)

Publications

No (6)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human MCFD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92882

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.5 kDa

Price:

20 µg/$150

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MCFD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107045

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.5 kDa

Price:

100 µg/$494

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Human MCFD2 Protein (Recombinant GST) (Full Length) - LS-G35976

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MCFD2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72560

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.5 kDa

Price:

20 µg/$1,107

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Human MCFD2 Protein (Recombinant) - LS-G675

Source:

E. coli

Tag:

None

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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Human MCFD2 Protein (Recombinant His) (aa27-146) - LS-G141065

Source:

E. coli

Sequence Length:

119 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

13.2 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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