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MASTL / GW
microtubule associated serine/threonine kinase-like
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
| Gene Name: | microtubule associated serine/threonine kinase-like |
| Family/Subfamily: | Protein Kinase , Provisional protein kinase |
| Synonyms: | MASTL, Greatwall protein kinase, HGWL, GWL, MAST-L, THC2, GREATWALL, GW, RP11-85G18.2 |
| Target Sequences: | NM_032844 NP_116233.2 Q96GX5 |
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