MAPK6 / ERK3

mitogen-activated protein kinase 6

ERK3, a MAPK type protein kinase, has been associated with the ERK MAPKs based on similarity of the catalytic domain. Compared to ERK1/2, ERK 3 lacks the activating tyrosine phosphorylation site and contains only a serine which is phosphorylated by MEK. ERK3 is primarily localized to the nucleus where it is believed to phosphorylate substrates in response to cell stress and damage. Specific ERK3 substrates are uncertain; however, studies have shown that ERK3 does not phosphorylate ERK1/2 substrates. The ERK3 gene maps to chromosome 15q21, a region associated with chromosomal abnormalities in acute nonlymphoblastic leukemias. Additionally, ERK3 kinase activity has been reported to be increased in colorectal cancers.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

MAPK6 / ERK3 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-SUMO (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human MAPK6 / ERK3 Protein (Recombinant GST) (Full Length) - LS-G29914

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

109.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MAPK6 / ERK3 Protein (Recombinant GST, N-terminus) (aa612-721) - LS-G59744

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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MAPK6 / ERK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99854

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.5 kDa

Price:

100 µg/$494

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Human MAPK6 / ERK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75870

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.5 kDa

Price:

20 µg/$150

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Human MAPK6 / ERK3 Protein (Recombinant His, N-Terminal) - LS-G144232

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

82.5 kDa

Price:

50 µg/$419

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Human MAPK6 / ERK3 Protein (Recombinant His-SUMO) (Full Length) - LS-G20950

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

98.61 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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