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Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.
Gene Name: | suppression of tumorigenicity 5 |
Synonyms: | ST5, DENN/MADD domain containing 2B, DENND2B, HeLa tumor suppression 1, HTS1, p126 |
Target Sequences: | NM_005418 NP_005409.3 P78524 |
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