Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
GLUP / PACRG is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | PARK2 co-regulated |
Synonyms: | PACRG, GLUP, HAK005771, PARK2 co-regulated, PARK2CRG, RP3-495O10.2, PARK2 coregulated gene protein |
Target Sequences: | NP_689623.2 Q96M98 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.