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Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Gene Name: | epidermal growth factor receptor pathway substrate 15-like 1 |
Synonyms: | EPS15L1, Eps15-related protein, EPS15R |
Target Sequences: | NM_021235 NP_067058.1 Q9UBC2 |
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