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EML4 is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants.
Gene Name: | echinoderm microtubule associated protein like 4 |
Synonyms: | EML4, C2orf2, EMAP-4, EMAPL4, Ropp 120, ELP120, ROPP120 |
Target Sequences: | NM_019063 NP_061936.2 Q9HC35 |
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