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Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Gene Name: | engulfment and cell motility 2 |
Synonyms: | ELMO2, PH domain protein CED12A, CED-12, Ced-12 homolog 2, CED12, CED12A, ELMO-2, Engulfment and cell motility 2, HCed-12A, KIAA1834, Protein ced-12 homolog A |
Target Sequences: | Q96JJ3 Q96JJ3 |
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