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ECaC / TRPV5
transient receptor potential cation channel, subfamily V, member 5
Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca2+-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
| Gene Name: | transient receptor potential cation channel, subfamily V, member 5 |
| Family/Subfamily: | Ion Channel , Calcium channel - TRP |
| Synonyms: | TRPV5, CAT2, Calcium transport protein 2, Calcium transporter 2, ECAC1, Epithelial calcium channel 1, ECaC, OTRPC3, Osm-9-like TRP channel 3 |
| Target Sequences: | NM_019841 NP_062815.3 Q9NQA5 |
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