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Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein.
Gene Name: | dynein, light chain, Tctex-type 1 |
Synonyms: | DYNLT1, CW-1, Protein CW-1, Tctex-1, TCTEL1, TCTEX1 |
Target Sequences: | NM_006519 NP_006510.1 P63172 |
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