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DGAT1

diacylglycerol O-acyltransferase 1

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.

Gene Name: diacylglycerol O-acyltransferase 1
Synonyms: DGAT1, ACAT-related gene product 1, ACAT related gene product 1, ARGP1, ARAT, DGAT, Diglyceride acyltransferase, AGRP1
Target Sequences: NM_012079 NP_036211.2 O75907

Publications (3)

1
High fatty acid availability after exercise alters the regulation of muscle lipid metabolism. Newsom SA, Schenk S, Li M, Everett AC, Horowitz JF. Metabolism: clinical and experimental. 2011 60:852-9. [PubMed:20870251] [PMC:PMC3011035]
2
High muscle lipid content in obesity is not due to enhanced activation of key triglyceride esterification enzymes or the suppression of lipolytic proteins. Li M, Paran C, Wolins NE, Horowitz JF. American journal of physiology. Endocrinology and metabolism. 2011 300:E699-707. [PubMed:21285405] [PMC:PMC3074947]
3
DGAT1 mutation is linked to a congenital diarrheal disorder. Haas JT, Winter HS, Lim E, Kirby A, Blumenstiel B, DeFelice M, Gabriel S, Jalas C, Branski D, Grueter CA, Toporovski MS, Walther TC, Daly MJ, Farese RV. The Journal of clinical investigation. 2012 122:4680-4. (WB; Mouse) [PubMed:23114594] [PMC:PMC3533555]

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Products
Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
DGAT1 (4)
No (4)
10His, N-terminus + Myc, C-terminus (1)
His (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Purified (1)
DGAT1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
55.1 kDa
20 µg/$150
DGAT1 Protein - Recombinant Diacylglycerol-O-Acyltransferase Homolog 1 By SDS-PAGE
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E. coli
His
31.1 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
DGAT1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
55.1 kDa
100 µg/$494
DGAT1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus + Myc, C-terminus
37.1 kDa
100 µg/$1,128; 20 µg/$721
Viewing 1-4 of 4 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).