DCLK2 / DCAMKL2

doublecortin-like kinase 2

DCLK2 / DCAMKL2 is a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

DCLK2 / DCAMKL2 (3)

Publications

No (3)

Tag

Myc-DDK (Flag) (3)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (2)

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Human DCLK2 / DCAMKL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92290

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.4 kDa

Price:

20 µg/$215

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DCLK2 / DCAMKL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120296

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.4 kDa

Price:

100 µg/$710

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Human DCLK2 / DCAMKL2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72414

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.4 kDa

Price:

20 µg/$1,107

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