CHMP1A

charged multivesicular body protein 1A

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

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Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

CHMP1A (8)

Publications

No (8)

Tag

GST (2)

His (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human CHMP1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80894

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.5 kDa

Price:

20 µg/$150

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Human CHMP1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80895

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.5 kDa

Price:

20 µg/$150

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CHMP1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119800

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.5 kDa

Price:

100 µg/$494

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CHMP1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117757

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.5 kDa

Price:

100 µg/$494

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Human CHMP1A Protein (Recombinant GST) (Full Length) - LS-G29647

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

47.19 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CHMP1A Protein (Recombinant GST) (Full Length) - LS-G29648

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

48.1 kDa

Price:

2 µg/$439

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Human CHMP1A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67871

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.5 kDa

Price:

20 µg/$1,107

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Human CHMP1A Protein (Recombinant His) - LS-G2058

Source:

E. coli

Tag:

His

Price:

20 µg/$361; 100 µg/$739; 4 µg/$261

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