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Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5.
Gene Name: | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 |
Synonyms: | ARAP1, Cnt-d2, Centaurin, delta 2, Centaurin-delta-2, CENTD2, KIAA0782 |
Target Sequences: | NM_001040118 NP_001035207.1 Q96P48 |
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