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Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
Gene Name: | chromobox homolog 3 |
Synonyms: | CBX3, Chromobox homolog 3, HP1Hs-gamma, Heterochromatin-like protein 1, Modifier 2 protein, HP1-GAMMA, Chromobox protein homolog 3, HECH, HP1 gamma, HP1 gamma homolog |
Target Sequences: | NM_016587 NP_057671.2 Q13185 |
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