URI1 / NNX3

URI1, prefoldin-like chaperone

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

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Products

Antibodies (26)

Proteins (5)

Type

Over-Expression Lysate (2)

Primary (26)

Recombinant (3)

Target

URI1 / NNX3 (31)

Reactivity

Human (26)

Mouse (4)

Rat (2)

Chimpanzee (3)

Gibbon (3)

Horse (3)

Monkey (4)

Orangutan (3)

Rabbit (3)

Application

IHC (6)

IHC-P (1)

WB (23)

ELISA (9)

IF (1)

IP (3)

Peptide-ELISA (3)

Host

rabbit (25)

mouse (1)

Isotype

IgG (20)

Clonality

polyclonal pc (26)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (15)

Epitope

aa347-376 (7)

aa359-408 (4)

C-Terminus (2)

390-470 aa, C-terminal (1)

aa122-171 (1)

aa350-400 (1)

aa415-464 (1)

aa458-508 (1)

Publications

No (31)

Tag

GST (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Select

URI1 / NNX3 Antibody (aa347-376) LS-C97594

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa347-376) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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URI1 / NNX3 Antibody (aa359-408) LS-C111293

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa359-408) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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URI1 / NNX3 Antibody (aa359-408, HRP) LS-C454197

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa359-408) (HRP) Antibody

Reactivity:

Rabbit, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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URI1 / NNX3 Antibody (aa359-408, Biotin) LS-C454195

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa359-408) (Biotin) Antibody

Reactivity:

Rabbit, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

URI1 / NNX3 Antibody (aa359-408, FITC) LS-C454196

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa359-408) (FITC) Antibody

Reactivity:

Rabbit, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

URI1 / NNX3 Antibody LS-C807327

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

URI1 / NNX3 Antibody LS-C831179

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

URI1 / NNX3 Antibody (390-470 aa, C-terminal) LS-C385920

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (390-470 aa, C-terminal) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

URI1 / NNX3 Antibody LS-C824552

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

URI1 / NNX3 Antibody (aa415-464) LS-C291381

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa415-464) Antibody

Reactivity:

Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

URI1 / NNX3 Antibody (aa122-171) LS-C200606

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa122-171) Antibody

Reactivity:

Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

URI1 / NNX3 Antibody LS-C675056

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

URI1 / NNX3 Antibody (HRP) LS-C672121

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

URI1 / NNX3 Antibody (FITC) LS-C672124

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• FITC

• Unconjugated
• HRP
• FITC

Select

URI1 / NNX3 Antibody (aa347-376) LS-C330637

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa347-376) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

URI1 / NNX3 Antibody (aa347-376, Biotin) LS-C220588

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa347-376) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

URI1 / NNX3 Antibody (aa347-376, FITC) LS-C220590

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa347-376) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

URI1 / NNX3 Antibody (aa347-376, Azide-free, HRP) LS-C220589

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa347-376) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

URI1 / NNX3 Antibody (aa347-376, PE) LS-C220591

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa347-376) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

URI1 / NNX3 Antibody (aa347-376, APC) LS-C220587

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa347-376) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• PE
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • PE
  • APC

Select

URI1 / NNX3 Antibody (C-Terminus) LS-C144147

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$688

Select

URI1 / NNX3 Antibody (aa350-400) LS-C287984

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa350-400) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

URI1 / NNX3 Antibody (aa458-508) LS-C287985

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (aa458-508) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

URI1 / NNX3 Antibody (C-Terminus) LS-C353085

Antibody:

URI1 / NNX3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

Select

URI1 / NNX3 Antibody LS-C306622

Antibody:

URI1 / NNX3 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

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