Target
Human TNFSF11 / RANKL / TRANCE
Synonyms
TNFSF11 | CD254 | CD254 antigen | HRANKL2 | OPTB2 | TRANCE | ODF | OPGL | SOdf | Osteoprotegerin ligand | RANKL
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant Human Tumor necrosis factor ligand superfamily member 11 protein (73-306AA)
Specificity
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).