Human Sialylated Lewis a / CA 19-9

Mouse

Human (tested or 100% immunogen sequence identity)

IgM,k Monoclonal

SPM588

Unconjugated

PEG purified

Azide-free, BSA-free. Also available Unmodified.

Precipitin lines obtained after immunodiffusion using mAb 116-NS-19-9 and mucins isolated from an ovarian cyst of a Lewis A+B- patient (0Le) were used as the immunogen for the CA19-9 antibody.

Human CA 19-9

• IHC - Paraffin (10 µg/ml)

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. CA19-9, a carbohydrate epitope expressed on a high MW (>400kDa) mucin glycoprotein, is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewisa and/or Lewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas. Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery. When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings. This mAb is superb for staining of formalin-fixed, paraffin-embedded tissues. Optimal dilution of the CA19-9 antibody should be determined by the researcher. No special pretreatment is required for the immunohistochemical staining of formalin-fixed, paraffin-embedded tissues.

PBS, BSA/sodium azide free

Store at -20°C or lower. Aliquot to avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.