Target
Human CD225 / IFITM1
Synonyms
IFITM1 | 9-27 | CD225 antigen | Dispanin subfamily A member 2a | DSPA2a | IFI17 | LEU13 | CD225 | Interferon-induced protein 17 | Leu-13 antigen
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Immunogen
Synthetic peptide from the N-Terminus of human IFITM1 (MHKEEHEVAVLGPPPST, aa1-17 of UniProt P13164). Percent identity by BLAST analysis: Human (100%); Elephant (88%).
Specificity
Human CD225 / IFITM1
Applications
- IHC
- IHC - Paraffin (0.5 - 1 µg/ml)
- IHC - Frozen (0.5 - 1 µg/ml)
- Western blot (0.5 - 1 µg/ml)
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Usage
Interferon-induced Transmembrane Protein 1 (IFITM1), also called Interferon-induced Protein 17 (IFI17). IFITM1 activity is required for primordial germ cells (PGCs) transit from the mesoderm into the endoderm, and that it appears to act via a repulsive mechanism, such that PGCs avoid Ifitm1-expressing tissues. It is mapped to Chr.11 and belongs to the family of interferon-induced transmembrane proteins (Ifitm/mil/fragilis), which encodes cell surface proteins that may modulate cell adhesion and influence cell differentiation. Interferon-inducible membrane proteins of approximately 17 kDa have been suggested to play a role in the antiproliferative activity of interferons based on their pattern of induction in interferon-sensitive and -resistant cell lines and the ability of a membrane fraction enriched in 17-kDa proteins to inhibit cell growth.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
Reconstitution
Reconstitute in sterile distilled water.
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
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